Drug Update Quizz

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Echinocandins are noncompetitive inhibitors of beta-D-glucan synthesis by interfering key catalytic subunits (Fks1p and Fks2p) in the beta-(1,3)-D-glucan synthase enzyme complex, echinocandins deplete cell wall glucan crosslinking, resulting in a markedly weakened cell wall structure. Which of the following is true for their clinical use ?

All of the above statements are true for echinocandins activity against biofilm-embedded Candida species.

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