Drug Update Quizz 2Created on June 21, 2022EchinocandinsEchinocandins are noncompetitive inhibitors of beta-D-glucan synthesis by interfering key catalytic subunits (Fks1p and Fks2p) in the beta-(1,3)-D-glucan synthase enzyme complex, echinocandins deplete cell wall glucan crosslinking, resulting in a markedly weakened cell wall structure. Which of the following is true for their clinical use ? Under sessile biofilm-like conditions, the MICs for amphotericin B and fluconazole may increase by 10- to 1000-fold whereas echinocandin MICs are minimally affected when tested in biofilm versus non-biofilm conditions. Echinocandins may be particularly useful antifungal agents for prosthetic device or catheter-associated infections in which biofilm-embedded organisms can be associated with recurrent candidemia. Biofilm growth in C. albicans is associated with increased secretion of carbohydrates, including beta-(1,3)-D-glucan. All of the above statements are true for echinocandins activity against biofilm-embedded Candida species. All of the above statements are true for echinocandins activity against biofilm-embedded Candida species. Change/Click on page numbers below for next Question Pages: 1 2 3 4 5 6
