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Tag: Extranodal NK/T Cell Lympoma

Extranodal NK/T Cell Lympoma, Nasal Type – Mini Review

August 31, 2021October 31, 2021 Hem Updates

Author: Sujeet Kumar @sujeethemat Some Salient points:- [1] Approximately 70-75% cases are diagnosed in Limited stage (Stage I and II) [2] Median Age at presentation = 50 years [3] Delition 6q21 is MC cytogenetic aberation. [4] Presence of EBV is Read More …

Malignant Hematology, Mini Review NHL, NHLsExtranodal NK/T Cell LympomaLeave a comment

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1/04/2022: FDA approved axicabtagene ciloleucel (Yescarta, Kite Pharma, Inc.) for adult patients with large B-cell lymphoma (LBCL) that is refractory to first-line chemoimmunotherapy or relapses within 12 months of first-line chemoimmunotherapy. It is not indicated for the treatment of patients with primary central nervous system lymphoma. Approval was based on ZUMA-7 trial.
29/10/2021: FDA granted accelerated approval to asciminib (Scemblix, Novartis AG) for patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), previously treated with two or more tyrosine kinase inhibitors (TKIs), and approved asciminib for adult patients with Ph+ CML in CP with the T315I mutation.
1/10/2021: FDA approved brexucabtagene autoleucel for adult patients with relapsed or refractory B-cell ALL. Efficacy was evaluated in ZUMA-3 (NCT02614066), a single-arm multicenter trial that evaluated brexucabtagene autoleucel, a CD19-directed chimeric antigen receptor (CAR) T-cell therapy, in adults with relapsed or refractory B-cell precursor ALL.
14/9/2021: FDA granted accelerated approval to zanubrutinib for adult patients with relapsed or refractory marginal zone lymphoma (MZL) who have received at least one anti-CD20-based regimen.
1/9/2021: FDA approved zanubrutinib for adult patients with Waldenström’s macroglobulinemia (WM). Zanubrutinib was investigated in ASPEN (NCT03053440), a randomized, active control, open-label trial, comparing zanubrutinib and ibrutinib in patients with MYD88 L265P mutation (MYD88MUT) WM.
16/6/2021: FDA approved avapritinib for adult patients with advanced systemic mastocytosis (AdvSM), including patients with aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematological neoplasm (SM-AHN), and mast cell leukemia (MCL).
15/12/2021: FDA approved abatacept for the prophylaxis of acute graft versus host disease (aGVHD), in combination with a calcineurin inhibitor (CNI) and methotrexate (MTX), in adults and pediatric patients 2 years of age and older undergoing hematopoietic stem cell transplantation (HSCT) from a matched or 1 allele-mismatched unrelated donor. This is the first drug approved to prevent aGVHD. Approval was based on GVHD-1 (NCT 01743131) trial.
23/11/2021: FDA approved maribavir as the first drug for treating adults and pediatric patients (12 years of age and older and weighing at least 35 kilograms) with post-transplant cytomegalovirus (CMV) infection/disease that does not respond (with or without genetic mutations that cause resistance) to available antiviral treatment for CMV.
22/9/2021: FDA approved ruxolitinib for chronic graft-versus-host disease (cGVHD) after failure of one or two lines of systemic therapy in adult and pediatric patients 12 years and older. Efficacy was evaluated in REACH-3, a randomized, open-label, multicenter clinical trial of ruxolitinib compared to best available therapy (BAT) for corticosteroid-refractory cGVHD after allogeneic stem cell transplantation. (Read more about Ruxolitinib)
16/7/2021: FDA approved belumosudil, a kinase inhibitor, for adult and pediatric patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic therapy.

2
Created on June 21, 2022
Echinocandins

Echinocandins are noncompetitive inhibitors of beta-D-glucan synthesis by interfering key catalytic subunits (Fks1p and Fks2p) in the beta-(1,3)-D-glucan synthase enzyme complex, echinocandins deplete cell wall glucan crosslinking, resulting in a markedly weakened cell wall structure. Which of the following is true for their clinical use ?

All of the above statements are true for echinocandins activity against biofilm-embedded Candida species.

All Drug Update Quizes

3
Created on June 21, 2022
Poll of the Week 6

Micafungin, caspofungin and anidulafungin are not active at clinically relevant concentrations against all of these except ?

Micafungin, caspofungin and anidulafungin are not active at clinically relevant concentrations against Zygomycetes, Cryptococcus neoformans, Fusarium spp., or Trichosporon spp.

Echinocandins show fungicidal activity against both C. albicans and a large group of non-albicans species, including species such as C. glabrata and C. krusei, which are intrinsically resistance to triazoles, and C. lusitaniae resistance to amphotericin B.

In cases of Aspergilli, echinocandins have fungistatic activity and reduce invasion via damage of hyphae and branching.

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